The Widget Anchors go through different stages of initialization:
VARIABLES_LOADED[]
At the time your frame recieves this event, its anchors are initialized to the values in the xml file.
PLAYER_ENTERING_WORLD[]
When handling this event for a frame which parent is UIParent, World of Warcraft deletes all anchors and loads the layout data from layout-cache.txt. If the frame layout data have not been saved in the cache (the user has never moved the frame with the mouse), Frame:GetLeft(), Frame:GetBottom(), Frame:GetRight() and Frame:GetTop() return nil.